|
KMID : 0366220170520020095
|
|
Korean Journal of Hematology
2017 Volume.52 No. 2 p.95 ~ p.99
|
|
|
Dapsone therapy for refractory immune thrombocytopenia patients: a case series
|
|
Lee Ji-Yun
Lee Jeong-Ok
Jung Joo-Young
Bang Soo-Mee
|
|
|
Abstract
|
|
|
Background: Dapsone has been recommended as a second-line immunosuppressive agent for patients with immune thrombocytopenia (ITP).
Methods: We retrospectively analyzed the efficacy and safety of dapsone therapy in patients with ITP.
Results: Nine ITP patients were treated with dapsone at a dose of 50?100 mg/day between May 2013 and March 2016. All patients were refractory to multiple previous treatments, with a median of 7 agents (range, 4?8), and 3 patients had undergone a previous splenectomy. The median pre-treatment platelet count was 4×109/L (range, 3?27×109/L). Only 1 patient (11.1%) responded to dapsone therapy. No severe adverse events were observed, except for 1 case of dapsone hypersensitivity syndrome.
Conclusion: Although dapsone is still useful for some patients, it may be ineffective in heavily pretreated patients with profound thrombocytopenia.
|
|
|
KEYWORD
|
|
|
Immune thrombocytopenia, Dapsone, Efficacy, Toxicity
|
|
|
FullTexts / Linksout information
|
|
|
|
|
Listed journal information
|
|
  
|